Natural Lupinus Polyphyllus Extract Lupeol For Anti Oxidation

Natural Lupinus Polyphyllus Extract Lupeol For Anti Oxidation

Product Description

Multi-leaf lupine (scientific name: Lupinus polyphyllus Lindl.) annual herb, up to 100 cm high. Stems erect, palmately compound, leaflet lanceolate to oblanceolate, leaf blade thick, racemose, flowers densely dense, alternate, inflorescences slender, stalk very short, sessately sessate, sessile, corolla blue Color, flag and keel with white markings. The pods are oblong-linear, seed ovate, flat, striate, smooth. Flowering from June to August, results from July to O
Lupeol is a pharmacologically active triterpenoid, It is found in a variety of plants, including mango and acacia visco. It is also found in dandelion coffee.The products is extract by crataeva nurvala. It has several medicinal properties, one being anti-inflammatory and It also can decrease swelling.

Basic Information

Function of Lupeol

1. Anti-tumor effect

(1) inhibition of melanoma: lupanol can inhibit the growth and induce differentiation of melanoma in mice. Induction of melanoma cell differentiation is achieved by activating the mitogen-activated protein kinase (MAKP) pathway, and the similarities and differences of the c-3 structure of lupine ring play a key role in the activation of the MAKP pathway.

Lupanol has an inhibitory effect on metastasis of malignant melanoma, and its mechanism is mainly related to the Wnt/ catenin signal pathway, but has nothing to do with the MAKP pathway.

(2) inhibition of skin cancer in mice

Lupanol can inhibit the occurrence of skin cancer and the expression of tumor markers.

(3) inhibitory effect on breast cancer

Lupanol can inhibit the growth of breast cancer cells. It indicates that the inhibitory effect of lupanol on breast cancer cells does not depend on ER, but has a certain correlation. Effects of lupanol on human epidermal growth factor receptor 2 (HER2) in breast cancer cells.

(4) inhibiting and inducing apoptosis of prostate cancer cells

In endocrine-related tumors, besides breast cancer cells, lupanol also has an inhibitory effect on prostate cancer. Lupanol can inhibit the growth and induce apoptosis of prostate cancer cell lines LNCaP and CWR22Rr1 in a dose-dependent manner, mainly by activating the fas receptor-mediated apoptosis pathway. In addition, lupanol also significantly inhibited the growth of transplanted prostate cancer.

(5) inhibition and apoptosis induction of pancreatic cancer

Lupanol inhibits the growth of pancreatic cancer, and inhibits Ras pathway to induce apoptosis of pancreatic cancer cells.

(6) inhibitory effect on liver cancer cells

In vitro and in vivo, lupanol inhibited the self-renewal ability of tumor initiatingcell (TIC) cells in liver cancer. In addition, lupanol inhibited the tumorigenic ability of TIC cells in thymus-free nude mice, and down-regulated the expression level of CD133, a marker of TIC cells.

(7) inhibition of leukemia cells

Lupanol can inhibit the growth of leukemia cells and induce apoptosis. The inhibition of lupanol on leukemia cells is related to carbonylation of lupanine ring.

(8) inhibitory effect on other tumors

Lupanol has an inhibitory effect on head and neck tumors. Lupanol has certain inhibitory effect on human ovarian cancer cells.

2. Anti-inflammatory effect

3. Oxidation resistance

Application of Lupeol

1.Lupeol is a triterpenes compound,has the function of Antiinflammation , antioxidant , promote healing of skin wound ,and so on,Lupeol can be used in the Cosmetic products.

2.Lupeol can be used in the Health Food and Pharmaceutical Industry. It also can be used directly as the raw material in capsule filling.