Alpinia Seed Cardamom Seed Powder Cardamonin 98% CAS 18956-16-6

Alpinia Seed Cardamom Seed Extract Cardamonin 98% Powder CAS 18956-16-6

Cardamonin (CDN), with a structure of 2', 4'-two-axis-6'-a clip ear emission, mainly anti-pigmentation, anti-tumor, anti-mutagenic, reflex, anti-oxidation and anti-bacterial organisms active. A large amount of research evidence shows the chemical inhibitory effect of cardamom on the chemical substances E2 (PGE2), nitric oxide (NO), tumor biotin (TNF)-ɑ, interleukin (IL)-1β and IL-6, and inhibition of NF -TLR4 related to κB signal. TLR4 is a gene derived from NF-κB. Our regulatory effect on TLR4/NF-B signaling is only in the previous report: the relevance of cardamomine to mice. The protective effect of destruction may be related to the expression of TLR4 in environmental tissues, the inhibition of NF-κB mitogen-activated proteolysis and the reduction of mediated release.

Cardamonin has promising potential in cancer prevention and therapy by interacting with proteins and modifying the expressions and activities, including factors of cell survival, proliferation, and angiogenesis. In our precious study, we have demonstrated that cardamonin suppressed vascular endothelial growth factor- (VEGF-) induced angiogenesis as evaluated in the mouse aortic ring assay. It is also known that microRNAs (miRNAs) play important roles in angiogenesis. Herein, we hypothesized wh antiangiogenesis effect of cardamonin in human umbilical vein endothelial cells (HUVECs) triggered by VEGF was associated with miRNAs. We found that cardamonin reduced the miR-21 expression induced by VEGF in HUVECs. Treatment with miR-21 mimics abolished the effects of cardamonin on VEGF-induced cell proliferation, migration, and angiogenesis in HUVECs. However, treatment with miR-21 inhibitors presented the opposite effects, indicating the vital role of miR-21 in this process. Our study provides a new insight of the preliminary mechanism of anti-VEGF-induced angiogenesis by cardamonin in HUVECs.

Function&Application:

1.Cardamomin Powder can anti-inflammatory.
2.Cardamomin powder can inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells.
3.Cardamomin powder can inhibits TXB2 production via the COX-1 and COX-2 pathways.
4.Cardamomin powder can Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.
5.Cardamomin Powder can make the skin whitening .
6. Pharmaceutical as capsules or pills;
7. Health products as capsules or pills.
8. Used in the field of cosmetics